Methylfolate is used in the body for a variety of important processes, including detoxification, DNA synthesis and repair, gene expression, foetal development and the metabolism of neurotransmitters, such as dopamine and serotonin [a].

Folate is the natural form of B9, and is found in foods such as dark leafy greens, beans, legumes, liver and avocados. You might also have heard of folic acid. Folic acid is a synthetic (man-made) form of folate, and is often found in fortified foods, such as cereals, bread and is also added to prenatal supplements.

In terms of fertility, folate supplementation can help prevent certain birth defects, also known as neural tube defects, such as spina bifida [b], and inadequate levels have also been seen to influence fertility, and result in elevated homocysteine, recurrent miscarriage [c], preeclampsia and low energy and mood.

According to the NHS, the standard advice is to take 400 microgram folic acid supplement daily until you’re 12 weeks pregnant [d], at least 2-3 months prior to trying for a baby.

Now, when it comes to our genetics, a gene found in every cell of our body called MTHFR (methylenetetrahydrofolate reductase -what a mouthful! ) instructs an enzyme to aid in the conversion of folate into its active form, methylfolate [e].

What you perhaps didn’t know is that it can be quite common to have a problem with this MTHFR gene. This common problem, which we refer to as a genetic variant, means the MTHFR enzyme doesn’t function optimally, folate isn’t converted into its active form, and you are therefore referred to as a “poor methylator”.

If a problem with the MTHFR gene is identified, fear not, it’s possible to take the active form of folate, methylfolate, which essentially means that it’s more bioavailable (ready to use) without reliance on the enzyme.

We also recommend that you avoid foods that contain the synthetic form of folate (folic acid) as well as supplements that contain folic acid, because it can reduce the availability of methylfolate even further if you’re a “poor methylator” [f].

In summary, if you’re planning on trying to conceive within the next 2-3 months, a good starting point would be carry out DNA test and get your MTHFR gene checked as part of our Female Health Report to see if you are converting folate efficiently into its active form, and if not, we will talk you through your results, giving clear advice, as well as providing other complimentary dietary recommendations that can support you on your preconception and fertility journey!